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| Registros recuperados: 62 | |
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| Wessel, Nathalie; Menard, Dominique; Pichavant-rafini, K.; Ollivier, H.; Le Goff, Jean-michel; Burgeot, Thierry; Akcha, Farida. |
| The benzo[a]pyrene is a polycyclic aromatic hydrocarbon known to be genotoxic, mutagenic and carcinogenic in higher vertebrates. The aim of this study was to evaluate in vitro the enzymatic and genotoxic effects of BaP in a benthic fish species, Solea solea. Sole hepatocytes were exposed to BaP in order to measure the modulation of ethoxyresorufin-o-deethylase (EROD) activity and the DNA strand breaks induced by BaP metabolism. Exposures were performed in both culture flasks and microplate wells in order to check for the possible miniaturization of the exposure system. Moreover, sole liver microsomes were exposed to BaP in the presence of standard DNA in order to assess the potential formation of DNA adducts in sole. The results demonstrated the ability of... |
| Tipo: Text |
Palavras-chave: Genotoxicity; Sole; BaP; DNA strand breaks; EROD; DNA adducts. |
| Ano: 2010 |
URL: http://archimer.ifremer.fr/doc/00018/12968/9944.pdf |
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| Parmentier, Koen F. V.; Verhaegen, Yves; De Witte, Bavo P.; Hoffman, Stefan; Delbare, Daan H. R.; Roose, Patrick M.; Hylland, Ketil D. E.; Burgeot, Thierry; Smagghe, Guy J.; Cooreman, Kris. |
| The restrictions and the concerted action of the global ban on the use and presence of tributyltin (TBT) in marine applications to protect ecosystems in the marine environment in 2008 was mainly based on the economic impact on shellfish industries and the dramatic extinction of local mollusk populations in the past. In contrast to the vast datasets on effects on mollusks, the knowledge on impacts on species from other taxa remained in the uncertain until almost two decades ago. The assumption on a long-term TBT-mediated pernicious metabolic bottom–up regulation of the crustacean Crangon crangon population was provoked by the outcome of an EU-project ‘Sources, Consumer Exposure and Risks of Organotin Contamination in Seafood.’ This study reported high TBT... |
| Tipo: Text |
Palavras-chave: Tributyltin; Crangon crangon; Endocrine disruption; Ecosystem impact; Ecdysteroids; Ecdysteroid receptor. |
| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00585/69727/67617.pdf |
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| Registros recuperados: 62 | |
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